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c iap1 2  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology c iap1 2
    C Iap1 2, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 328 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c+iap1+2/pmc08125413-211-7-13?v=Santa+Cruz+Biotechnology
    Average 95 stars, based on 328 article reviews
    c iap1 2 - by Bioz Stars, 2026-07
    95/100 stars

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    DNMT3A modulated IAPs expression to suppress tyrosine kinase inhibitors (TKIs)-induced cell apoptosis. A. The correlation analysis between DNMT3A expression and BIRCs (BIRC1-7) expression in 230 patients with non-small cell lung cancer (NSCLC) from the TCGA database. B. Heatmap of BIRCs (BIRC1-7) expression at the mRNA level in P1 and P2 cells. C. Heatmap of BIRCs (BIRC1-7) expression at the mRNA level in vector and DNMT3A overexpressed NCI-H3255 cells. D. Western blotting of c-IPA1 in P1, P2, vector and DNMT3A overexpressed NCI-H3255 cells. E. P1 and P2 cells were treated with SM-1295 (20 nM), erlotinib (2 μM), afatinib (5 μM) or in combination for 48 h. Then, cell apoptosis was assessed. F. Vector and DNMT3A overexpressed NCI-H3255 cells were treated with SM-1295 (20 nM), erlotinib (2 μM), afatinib (5 μM) or in combination for 48 h and then cell apoptosis was assessed. G. Representative images of c-IAP1 immunohistochemical staining in NSCLC tissues from recurrent and non-recurrent patients (n = 30, scale bar = 100 μm).

    Journal: American Journal of Cancer Research

    Article Title: DNMT3A governs tyrosine kinase inhibitors responses through IAPs and in a cell senescence-dependent manner in non-small cell lung cancer

    doi:

    Figure Lengend Snippet: DNMT3A modulated IAPs expression to suppress tyrosine kinase inhibitors (TKIs)-induced cell apoptosis. A. The correlation analysis between DNMT3A expression and BIRCs (BIRC1-7) expression in 230 patients with non-small cell lung cancer (NSCLC) from the TCGA database. B. Heatmap of BIRCs (BIRC1-7) expression at the mRNA level in P1 and P2 cells. C. Heatmap of BIRCs (BIRC1-7) expression at the mRNA level in vector and DNMT3A overexpressed NCI-H3255 cells. D. Western blotting of c-IPA1 in P1, P2, vector and DNMT3A overexpressed NCI-H3255 cells. E. P1 and P2 cells were treated with SM-1295 (20 nM), erlotinib (2 μM), afatinib (5 μM) or in combination for 48 h. Then, cell apoptosis was assessed. F. Vector and DNMT3A overexpressed NCI-H3255 cells were treated with SM-1295 (20 nM), erlotinib (2 μM), afatinib (5 μM) or in combination for 48 h and then cell apoptosis was assessed. G. Representative images of c-IAP1 immunohistochemical staining in NSCLC tissues from recurrent and non-recurrent patients (n = 30, scale bar = 100 μm).

    Article Snippet: The primary antibodies included anti-DNMT3A (ab188470, Abcam, UK), anti-c-IAP1 (ab108361, Abcam, UK), anti-CDKN1A (ab109520, Abcam, UK) and anti-β-actin (ab8226, Abcam, UK).

    Techniques: Expressing, Plasmid Preparation, Western Blot, Immunohistochemistry, Staining